BCL2 and renal cell carcinoma: In fact, the combination of chloroquine and ABT-737, a small-molecule BH3 mimetic with very high affinity to Bcl-2, Bcl-xL, and Bcl-w, which induces apoptosis by inhibiting pro-survival Bcl-2 proteins and activating caspases, synergistically decreased RCC cell viability as compared to treatment with a single reagent, and the level of ROS was increased after treatment with ABT-737 and chloroquine [149].