For example, NOX2-derived ROS facilitate the metastasis of melanoma cells, by downmodulation of NK-cell function [53], immunosuppression by chronic myelomonocytic leukemia (which depends on NOX2 [54]), and cell proliferation—which is associated with NOX2 in gastric cancer [55]. The gene discussed is CYBB; the disease is chronic myelomonocytic leukemia.