In addition, NOX4 stimulates angiogenesis through the upregulation of vascular endothelial growth factor (VEGF)-A and hypoxia-inducible factor (HIF)-1α in a variety of cancers [65], and siRNA-mediated knockdown of NOX4 inhibited VEGF-induced endothelial cell migration and proliferation [66]. Here, VEGFA is linked to cancer.