EPAS1 and cancer: Taking into account the antiangiogenic activity of some puupehenones [8], namely, the reported pro-apoptotic effect of 8-epipuupehedione in endothelial and leukaemia cells [9], and the inhibitory activity of puupehenone on the HIF-2α transcriptional response [28], these compounds represent a very promising putative drug against cancer.