SPACA1 and Globozoospermia: In gene KO mouse studies, various genes (Atg7 [20], Csnk2a2 [21], Dpy19l2 [12], Gba2 [22], Golga2 [23], Gopc [24], Hrb [25], Hsp90b1 [26], Mfsd14a [27], Pick1 [10], Sirt1 [28], Slc9a8 [29], Smap2 [30], Spaca1 [31], Tmf1 [32], Vps54 [33], Zpbp1 [34]) were found to be associated with globozoospermia [4].