Moreover, in a recent study, Handa et al., observed elevated hepatic hepcidin expression in patients with NASH and in NAFLD patients who had hepatic iron deposition, while proinflammatory cytokines displayed elevated expression only in patients with NASH, suggesting a regulatory role for hepcidin in NAFL to NASH transition and in mitigating inflammatory responses [23]. Here, HAMP is linked to metabolic dysfunction-associated steatohepatitis.