Consistently, after AB treatment for 4 weeks, the expression of ZNF418 was also lower, but ANP and β-MHC levels were higher in hearts of cardiac hypertrophy mice than hearts of sham mice (P < 0.05, Fig 1B), and more significant changes were observed at 8week (P < 0.05, Fig 1B). Here, ZNF418 is linked to cardiac hypertrophy.