ANXA6 and muscular dystrophy: Anxa6, was also identified as a modifier of muscular dystrophy by its action on sarcolemmal repair itself [45], and the DBA/2J background harbors the risk allele for Anxa6. In order to discriminate the effects elicited by the Anxa6 and Ltbp4 genetic modifiers on sarcolemmal repair, we generated WT mice in the 129T2 background strain carrying the four homozygous combinations of mild and severe isoforms of Anxa6 and Ltbp4 (A6mild/L4mild; A6severe/L4mild; A6mild/L4severe; A6severe/L4severe).