However, fluctuating levels of inflammation / ALT are more characteristic of chronic hepatitis B infection and a study of one hundred and fifty HCV subjects who underwent a liver biopsy and LSM, showed no impact of ALT on LSM.[30] Despite these limitations, we believe the clinical message is strong, and the cohort is unique for the duration of long-term follow-up with paired liver fibrosis assessments. This evidence concerns the gene GPT and chronic hepatitis B virus infection.