We were not able to collect detailed data concerning [24–27] behavioural factors that have been associated with the natural history of CHC, including alcohol consumption, marijuana use and coffee consumption, were not included in our analysis.[28,29] Liver inflammation has been shown to alter LSMs and we potentially may have over estimated the degree of fibrosis in participants with high levels of ALT. This evidence concerns the gene GPT and cryohydrocytosis.