Elevations in NGAL precede changes in serum creatinine and can be used to diagnose AKI up to 48 hours prior to a clinical change in creatinine or urine output.[42, 43] Interestingly, although AVP preserved renal architecture at 18 hours, there were no differences between groups in terms of NGAL or oxidant damage, suggesting that the benefit of supplementing AVP may be transient. The gene discussed is LCN2; the disease is acute kidney injury.