Nevertheless, the CD30+ neoplastic HRS cell of HL represents only a small proportion (0.1–10%) of the total lymphoma cell population, which mainly comprises such reactive cell types as T and B lymphocytes, plasma cells, eosinophils, neutrophils, macrophages, and fibroblasts (Brown and Staudacher, 2014). The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.