Finally, there was no statistical correlation between CD30 expression in DLBCL and tumour response to brentuximab vedotin in a phase 2 study, which included 49 relapsed or refractory DLBCL patients, although all the responders had quantifiable CD30 expression by computer assisted digital video analysis immunohistochemistry (cIHC). Here, TNFRSF8 is linked to diffuse large B-cell lymphoma.