INS and Cachexia: 2,3,7,8-Tetrachlorodibenzodioxin (TCDD) increases notably ghrelin and glucagon, links these hormones to the wasting syndrome [41], and induces lipolysis through IGF-1, fibroblast growth factor 21 and aryl hydrocarbon receptor (AHR) Dichlorodiphenyltrichloroethane (DDT) [41] and triphenyltin [42] affect both glucose stimulated insulin secretion, as well as insulin secretion due to defective cAMP-dependent cytoplasmic Na+ concentration in β-cells.