PPARG and osteoporosis: Aklylphenols through glycerol-3-phosphate dehydrogenase activity and peroxisome proliferator activation of receptor γ (PPARγ) activation [51], phthalates, organotins tributyltin-triphenyltin, phthalate metabolites, brominated flame retardants [52], polybrominated diphenyl ethers, tetrabromobisphenol A (TBBPA) and mono-(2-ethylhexyl)tetrabromophthalate (METBP) [53], increase visceral fat, accumulate adipocytes in bones, resulting in lower bone density, osteoporosis and increased fracture risk through PPARγ, which regulates the balance between adipogenesis and osteogenesis [54].