Molecular players in obesity-induced inflammation include inhibitor of nuclear factor κ-B kinase subunit beta (IKKβ)/nuclear factor κB (NF-κB) pathway [33], Jun N-terminal kinases [34], inflammasome pathway through pregnane X receptor (PXR) activation [35], cyclooxygenase-2, B-cell lymphoma-extra large (Bcl-xL) [36], cytokines, and inducible nitric oxide synthase (iNOS) [37]. Here, NR1I2 is linked to obesity due to melanocortin 4 receptor deficiency.