AQP4 and optic neuritis: Aside from the presence of the AQP4 antibody, which is confirmatory for the SSTM disease, there are several clinical features that suggest its diagnosis, including the following: non-White ethnicity, advanced age, personal history of autoimmunity and tonic spasms, prior history of severe and bilateral optic neuritis with limited recovery, prior episode of uncontrollable nausea and vomiting, and lastly, the absence of oligoclonal bands in the CSF.