The fact that OVCAR3-sfRon cells had a very firm PDK1 expression compared to the absence of the protein’s expression in control OVCAR3 cells, reflects the importance of PDK1 in driving aggressiveness in ways that are not correlated to AKT, and that focus should be given on testing inhibitors of PDK1 alone or in combination with Ron inhibitors, especially in this type of ovarian cancer [33]. The gene discussed is PDK1; the disease is ovarian carcinoma.