Indeed, CAMKK2 was shown to regulate the phosphorylation of Akt at both the threonine and serine residues in ovarian cancer cells, and combined downregulation of the CAMKK2 and PDK1 proteins had comparable effects on Akt phosphorylation, as did pharmacological inhibition of CAMKK2 and PI3K. Here, PIK3CA is linked to ovarian cancer.