PIK3CA and cancer: A very interesting example of the redundant pathways adapted by cancer cells to promote their survival in different aspects was very recently demonstrated by Gocher et al. Previous studies have mentioned that Akt can be activated by Ca2+/calmodulin-dependent protein kinase kinase 2 (CAMKK2) in ovarian, prostate and embryonic kidney cells, however Gocher et al. addressed the question of whether ovarian cancer resistance to platinum was a consequence of a combined action of CAMKK and the canonical PI3K pathway.