The PI3K pathway holds an important role in embryonic stem cell fate, with the main effector being PDK1 [114], and in addition to the implication of the latter in cancer stem cells maintenance mentioned in previous sections, it has been shown that dual inhibition of checkpoint kinase 1 (CHK1) and PDK1 effectively eliminates glioblastoma stem-like cells responsible for resistance to therapy and tumour recurrence [115]. The gene discussed is PIK3CA; the disease is neoplasm.