PIK3CA and glioblastoma: Knockdown of this protein was shown to avert PtdIns(3,4,5)P3 increase following stimulation with insulin growth factor 1 (IGF1) in glioblastoma cells, and this study denoted that MTDH-induced galectin-1 increase might result in an increase of PtdIns(3,4,5)P3 levels and activation of the PI3K cascade.