For examples, statins are used for lowering cholesterol levels, as well as prevention of coronary heart diseases, heart attack and stroke, in which Rosuvastatin has the highest efficacy in reducing LDL-C than other statins at comparable doses, while atorvastatin may improve hepatic insulin sensitivity that adds a point in treating patients with both T2D and dyslipidemia [78]. The gene discussed is INS; the disease is type 2 diabetes mellitus.