Interestingly, early, highly active endothelial progenitor cells (EPCs), carrying the osteoblastic marker OC, appear to be strongly associated with unstable coronary artery disease suggesting that this particular EPC subset could mediate vascular calcification and abnormal vascular repair and may identify patients with a more unstable phenotype of atherosclerosis [24]. The gene discussed is BGLAP; the disease is atherosclerosis.