IFNGR2 and Hepatic fibrosis: Moreover, we have examined the role of genetic factors in the multifactorial etiology of liver fibrosis, and found for example that the single nucleotide polymorphism (SNP) of the interferon gamma receptor 2, a pro-inflammatory gene known to be associated with progression to liver fibrosis in chronic hepatitis C patients, also was related to liver stiffness in the Rotterdam Study participants [231].