We first studied whether canonical TRAIL signaling is intact in the AML cells; we set to quantitate three TRAIL‐induced genes, that is, IL‐8, E‐selectin, and BNIP3, in U937 and HL60 cells upon exposure with TRAIL (Liu et al., 2013; Wang et al., 2015). The gene discussed is BNIP3; the disease is acute myeloid leukemia.