In this study, it was reported that knockdown of Rab7L1 recapitulated degeneration observed with the expression of a familial PD mutant form of LRRK2 in rodent or Drosophila dopamine neurons, whereas Rab7L1 overexpression rescued the LRRK2 mutant phenotypes. This evidence concerns the gene LRRK2 and Parkinson disease.