Cyclin G-associated kinase (GAK) plays key roles for clathrin exchange as well as for clathrin uncoating (Lee et al. 2006) and single nucleotide polymorphisms (SNPs) in the GAK locus have been identified as risk factors for sporadic PD by genome-wide association studies (Nalls et al. 2014). The gene discussed is GAK; the disease is Parkinson disease.