PfEMP1 is an important target of naturally acquired immunity to malaria (Chanet al., 2012) and plays a central role in malaria pathology through interaction with host endothelial receptors such as ICAM-1 (Berendtet al., 1989), CD36 (Barnwellet al., 1989), CR1 (Roweet al., 1997) and endothelial protein-C receptor (EPCR) (Turneret al., 2013). This evidence concerns the gene CR1 and malaria.