In agreement with our results, the inhibitors of mitochondrial complex III (carboxin and antimycin A) and NADPH oxidase (apocynin) significantly inhibited the ROS level and migration with TMZ treatment, further indicating that inhibition of the ROS-mediated NF-κB pathway in TMZ treatment is an important antimigration mechanism in glioma cells. The gene discussed is FMO5; the disease is glioma.