AGT and endothelial dysfunction: Interestingly, when local adrenergic contractile tone is recovered by the fifteenth day after surgery [5, 15], the adrenergic inhibitory mechanism of AT1-mediated signaling is blunted, which prompts the compensatory upregulation of local angiotensinergic functionality by a ROS-dependent endothelial dysfunction that makes contralateral carotid hyperreactive to angiotensin II (AngII) until the thirtieth day after surgery [5, 16].