Caspase-3 has been implicated in cleavage of a proapoptotic kinase protein kinase C delta (PKCdelta) that mediates neuron death in both MPP+ and 6-OHDA cellular PD models (Da Costa, Masliah & Checler, 2003; Kanthasamy et al., 2006; Shimoke & Chiba, 2001). Here, PRKCD is linked to Parkinson disease.