Caspases are involved in the pathophysiology of PD through mediating dopaminergic neuron death from MPTP (Furuya et al., 2004; Qiao et al., 2017; Viswanath et al., 2001), promoting synuclein aggregation (Wang et al., 2016), and cleaving Transactivation response DNA-binding protein 43 (TDP-43), which is a primary component of Lewy bodies in PD (Kokoulina & Rohn, 2010). The gene discussed is SNCA; the disease is Parkinson disease.