Insulin treatment had a negative impact on diabetes-specific QoL, and the subgroup of insulin-treated patients with LADA did not differ from other insulin-treated groups (T2DM and T1DM) in this regard; however, the average weighted impact score was poorer in insulin-treated LADA subjects than in their corresponding T2DM counterparts. The gene discussed is INS; the disease is type 1 diabetes mellitus.