Pharmacogenetic induction of the inducible HO isoform (HO-1) leads to attenuation of adiposity along with restoration of insulin sensitivity and abatement of chronic inflammation, cardiomyopathy [18], and pathophysiological insults frequently associated with diet induced obesity [2, 3, 8, 11, 19–22]. This evidence concerns the gene HMOX1 and obesity due to melanocortin 4 receptor deficiency.