NLRP3 inflammasome-activated NLRP3/ASC-dependent inflammatory responses result in the release of significant amounts of caspase-1 and IL-1β, and these innate immune responses play an important role in diabetic cardiomyopathy, myocardial infarction, and MI/R injury [26–28]. Here, CASP1 is linked to diabetic cardiomyopathy.