The inflammasome inhibitor BAY11-7082 attenuated the infarct size and injury in diabetes and nondiabetes after MI/R by decreasing NLRP3 inflammatory activation, as evidenced by decreased expression of the NLRP3 inflammasome (NLRP3, procaspase-1, and ASC protein complexes), and downregulated the expression of caspase-1 (p10) and cytokine IL-1β. This evidence concerns the gene NLRP3 and diabetes mellitus.