In the present study, we found typical characteristics of pyroptosis in the diabetic myocardium and myocardial tissue after MI/R in diabetic models, including increased expression of activated caspase-1, IL-1β production following activation of the NLRP3 inflammasome, cytoplasmic swelling, and LDH release, which aggravated MI/R injury in diabetic rats. Here, CASP1 is linked to myocardial infarction.