LIPC and Hypercholesterolemia: Moreover, Wang et al.33 concluded that the impact of a single genetic factor on CAD risk could be more prominent when there were such other common genetic or environmental cardiovascular risk factors as obesity, smoking, hypercholesterolemia, and diabetes.38 It should also be noted that contrary to expectations, the LIPC -514T allele has not been previously shown to be inversely associated with CAD.