However, it has been shown that this polymorphism in the HL promoter is associated with a higher extent of CAD.13, 30 Hokanson et al.41 suggested that in patients with type 1 diabetes, the LIPC -480C > T polymorphism was associated with the extent of coronary calcification in a dosage-dependent manner. The gene discussed is LIPC; the disease is type 1 diabetes mellitus.