Moreover, ANRIL is thought to be involved in the expression regulation of the neighboring protein-coding genes like MTAP and CDKN2A, CDKN2B and atherosclerosis development through vascular remodeling, thrombogenesis, and plaque stability.23 CAD is categorized in complex genetic disorders, and some diseases that predispose to CAD such as diabetes have been reported to be allied to rs10757274, rs2383206, rs10757278, and rs1333049 on chromosome 9p21.3. This evidence concerns the gene CDKN2B and atherosclerosis.