To investigate the role of p40phox, one of the subunits of the NADPH oxidase, in host protective and inflammatory responses against Salmonella infection and in the regulation of the severity of bacterial-induced disease, p40phox−/− mice and C57BL/6 WT control mice were infected orally with 3 × 108 CFU of S. Typhimurium (SL1344 strain). Here, NCF4 is linked to Salmonella Infections.