These observations show that p40phox deficiency in mice may enhance the recruitment of phagocytes to the infection site by regulating the expression of KC, MCP1, and MIP2 during Salmonella infection and suggest that the excessive accumulation of granulocytes in the spleens of infected p40phox KO mice may thereby enhance the inflammatory response. The gene discussed is CXCL2; the disease is Salmonella Infections.