In particular, the UL7 tegument protein may be a factor restricting viral proliferation (Xu et al., 2016); the Vhs protein is capable of preventing antigen signal transfer to adaptive immunity from the innate immune response during infection (Samady et al., 2003; Paludan et al., 2011); and the LAT gene is related to latency establishment and maintenance (Thompson and Sawtell, 1997). Here, LAT is linked to infection.