Curcumin have beneficial effects on AD including antioxidative, anti-Aβ aggregation, and inhibition of acetylcholinesterase, β-secretase, and Aβ-induced inflammation in vitro as well as inhibition of tau phosphorylation and Aβ oligomerization in the brain in vivo (12, 18). The gene discussed is ACHE; the disease is Alzheimer disease.