DUSP6 and obesity due to melanocortin 4 receptor deficiency: Thus, in obesity, the animals presenting an increase in the hypothalamic MKP-3 also demonstrated a decrease in the phosphorylation of FoxO1 (by 54%, t = 2.88, df = 10, p = 0.0451) and Erk1/2 (by 51%, t = 4.900, df = 8, p = 0.0006; Figures 3A,B), corroborating our previous data.