NPPB and heart disorder: These guidelines include: (i) Normal or reduced levels of NT-proBNP are more common in non-cardiac conditions, while high levels are typical of cardiopathies, (ii) in animals with asymptomatic heart disease, high NT-proBNP levels may be misdiagnosed as having non-cardiac causes, such as a respiratory condition, and (iii) NT-proBNP levels have to be analyzed in the context of clinical record, physical examination, and conventional diagnosis methods like imaging [6,44].