Eosinophil infiltration and peripheral eosinophilia are dependent on the eosinophil-specific cytokine (IL-5) and chemokines (eotaxin and RANTES), which provoke an eosinophilic response in the peripheral blood and airways via the C-C chemokine receptor type 3 (CCR3) [26]. The gene discussed is IL5; the disease is Increased total eosinophil count.