Using an univariate logistic regression models including healthy subjects and patients with NSCLC, previous study finds that HSP27 shows an AUC of 0.870 (P < 0.0001) and suggests that serum HSP27 levels might serve as a possible tool to discriminate between early and advanced stages NSCLC18. The gene discussed is HSPB1; the disease is non-small cell lung carcinoma.