Furthermore, NSCLC patients at IIIB-IV stage (48.99 ± 14.49, 2−ΔΔCt) displayed a higher serum level of HSP27 mRNA than those at IIA-IIIA stage (34.81 ± 9.72, 2−ΔΔCt) (P < 0.001). This evidence concerns the gene HSPB1 and non-small cell lung carcinoma.