Based on the PLD SP and inflammatory cytokines network, two super networks were constructed with NSCLC- and SM-specific proteins such as PLD1/2, PRKCD, PTK2B, LPARs, RPTOR, NOTCH1, TJP1, laminins, mucins, and collagens as well as pathways found in this study. This evidence concerns the gene PTK2B and non-small cell lung carcinoma.