Curation of the PLD SP derived from the KEGG database with the information attained through data-mining and Pathway Studio® led to the formation of a super network constructed with several NSCLC (e.g. PRKCD, PTK2B, PLCB2, and ARFGEF1) and SM (e.g. PLD2, ARFGEF1, and RPTOR) hubs. The gene discussed is RPTOR; the disease is non-small cell lung carcinoma.