Tailoring the AAb profiling with a systems biology approach provides an excellent image of the network of AAbs targeting proteins which may be key drivers of cancer-interacting SPs such as PLD, PI3K-Akt, MAPK, EGF/EGFR, c-Met, Ras, DDR, IL-4, IL-6, and TGF-β SPs in the NSCLC and SM groups. Here, IL4 is linked to cancer.