Proteins such as cystic fibrosis transmembrane conductance regulator (CFTR), PRKCD, tight junction protein ZO-1 (TJP1), PTK2B, TIAM1, nucleoside diphosphate kinase A (NME1), phospholipase C beta 2 (PLCB2), brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1), and checkpoint kinase 1 (CHEK1) were NSCLC-specific hubs. The gene discussed is CHEK1; the disease is non-small cell lung carcinoma.