Similarly, critical pathways were found in the SM group, such as PI3K-Akt SP, pathways in cancer, extracellular matrix (ECM)-receptor interaction, Fc gamma R-mediated phagocytosis, microRNAs in cancer, glutamatergic synapse, Wnt SP, PLD SP, DNA damage response (DDR) only ATM dependent, alpha 6 Beta 4 SP, EGF/EGFR SP, neurogenic locus notch homolog protein (NOTCH) SP, transforming growth factor beta (TGF-β) SP, transcriptional misregulation in cancer, Forkhead box O (FoxO) SP, tight junction, and tumour necrosis factor (TNF) SP (Fig. 3b). The gene discussed is TNF; the disease is cancer.