Based on the KEGG and WikiPathways databases, significant SPs such as EGF/EGFR SP, HGFR SP, MAPK SP, PI3K-Akt SP, Ras SP, glycerophospholipid metabolism, glutamatergic synapse, ECM-receptor interaction, small cell lung cancer, microRNAs in cancer, DDR, and pathways in cancer identified via analysis of NSCLC and SM modules-related pathways, were also integrated in this super network. This evidence concerns the gene EGFR and cancer.