We observed a number of novel pathways can be affected by these miRNAs with the most interesting regarding what is known about AAT deficiency being ER protein processing due to altered expression of MAN1A2, HSP90AA1 and EDEM1, validated targets of miR-598, miR-199a-5p and miR-320a, respectively. Here, EDEM1 is linked to alpha 1-antitrypsin deficiency.