To demonstrate the usefulness of the proposed strategy, in the text below, I specifically consider two genes, CYPOR and HNF4A, listed at the top for cirrhosis; CYPOR is top-ranked according to ‘Single Gene Perturbations from GEO up’, whereas HNF4A is top-ranked based on ‘Single Gene Perturbations from GEO down’. This evidence concerns the gene HNF4A and Cirrhosis.