CD4 and neoplasm: Surprisingly, CD4 proliferation was decreased at the 1:1/2 co-culture ratio (Fig. 4B and Supplementary Figure 7A) and CD8 proliferation was increased at the 1:1/2, 1:1/8 and 1:1/32 co-culture ratios in the p65KO group compared to p65 control group, indicating an antiproliferative role of myeloid canonical NF-κB signaling on CD8+T cells under tumor condition (Fig. 4C and Supplementary Figure 7B).