p65KO mice implanted with GBM had statistically significant cellular reductions in CD45+ leukocyte (Fig. 2A), macrophage (F4/80+) (Fig. 2B), tumor-associated macrophage (CD68+) (Fig. 2C), MDSC (Gr1+ CD11b+) (Fig. 2D), and M2 macrophage (CD206+ or mannose receptor) (Fig. 2F) populations. This evidence concerns the gene MRC1 and neoplasm.