In the present study, we anticipated that deletion of NF-κB signaling in myeloid cells may limit the above mechanisms of M2 polarization, which was evident by the decreased M2 (CD206) macrophages and increased M1 (CD86) macrophages in GBM tumor-bearing p65 KO mice compared to control mice. The gene discussed is NFKB1; the disease is glioblastoma.