Our recent approach in this direction uncovered 4′-Demethyl deoxypodophyllotoxin glucoside (4DPG), a natural podophyllotoxin congener from the medicinal plant Podophyllum hexandrum as a strong anticancer candidate that modulates Chk2 activity to suppress proliferation, invasion and metastasis in aggressive cancer cells. The gene discussed is CHEK2; the disease is cancer.