MAPT and Mental deterioration: On the other hand, CSF levels of p-tau (APOE4: p = 0.45, r = −0.18; APOE3: p = 0.65, r = −0.10) (Fig. 4B) and Aβ1-42 did not correlate with cognitive decline in both APOE groups (APOE4: p = 0.78, r = 0.07; APOE3: p = 0.35, r = −0.21) (Fig. 4C).