Although we do not address other potential mechanisms, such as inflammation driven alterations of lipid, or insulin metabolism and insulin resistance47, this work identifies IFN-γ as a potential therapeutic target in psoriasis associated atherogenesis, and provides exciting avenues for further dissecting the shared pathogenic mechanisms between psoriasis and atherosclerosis, including the nature of the IFN-γ and TNF-α synergy, and sheds light on critical inflammatory mechanisms by which other chronic inflammatory conditions may affect, induce and accelerate atherosclerosis. Here, INS is linked to atherosclerosis.