In Hela cells, mTORC1 inhibition is probably due to rapid FTY720-elicited inhibition of LAT1 activity, as LAT1 is well known to be the main leucine transporter in most cancer cells42, and leucine is not only an essential amino acid and the most abundant amino acid in proteins, but also a key regulator of mTORC1 signaling15,43. Here, SLC7A5 is linked to cancer.