In this study, CCN3 levels were significantly increased in HCC cell lines with high metastatic potential (HCC-LM3 and HCC-97H), whereas relatively low CCN3 levels were detected in HCC cell lines with moderate-low metastatic potential (PLC, SMMC-7721, Bel-7402, and Hep3B) and in human liver cells (L02) (Fig. 2G). Here, CCN3 is linked to hepatocellular carcinoma.