Post-translational modifications56, variations in its association with other PRC2 subunits, such as SUZ12 and EED57 and the existence of PRC2-independent activity of EZH258,59, and the role of SNPs in their expression or functionality60–62 are some of the proposed reasons for this variability in the role of EZH2 in cancer survival. The gene discussed is SUZ12; the disease is cancer.