EZH2 and neoplasm: Moreover, it is known that EZH2 is overexpressed in tumour tissue as compared to healthy tissue14,15,18,20,51, and it has been suggested, and supported by convincing mechanicistic data, an oncogenic function of EZH2 related to PRC2 functioning that, through histone methylation, would lead to chromatin condensation repressing the expression of tumour suppressor genes52.