Remarkably, these genes (i.e., CXCR3/CCR5 ligands, and the transcription factors STAT1 and IRF1) are central in the induction of immune-mediated tumor rejection57, 60, 66 and their overexpression in resected tumors has been associated with favorable prognosis59, 61, 62. The gene discussed is IRF1; the disease is neoplasm.