CASP3 and neoplasm: -Mediate direct tumor cell killing by activation of intrinsic apoptosis via proteolysis of anti-apoptotic proteins or direct cleavage of caspase 3 [79]-Increase ROS production resulting in oxidative damage [79]-Can active caspase 1 to promote release of IL-1β [79]-Extracellular granzymes can activate macrophages to produce pro-inflammatory cytokines [79]