Because beta adrenergic signaling regulates the functions of many cell types relevant to cancer progression and metastasis, including vascular pericytes, adipocytes, fibroblasts, and immune cells [45,46,58], and beta adrenergic signaling pathways impact many aspects of cancer progression, including angiogenesis, inflammation, and lipid metabolism, [58,59], we now suspect much of the coordinated signaling between tumor cells and the TME is regulated through β-ARs. The gene discussed is CTBP1; the disease is cancer.