BRAF and histiocytic sarcoma: The high prevalence of BRAFV600E in two human hematopoietic malignancies led researchers to investigate the presence of BRAF mutations in canine hematopoietic cancers; however, BRAF mutations were not detected in any of 245 canine hematopoietic cancers including tumors of histiocytic (histiocytic sarcoma and histiocytoma), lymphoid (lymphoma, plasmacytoma and acute and chronic lymphocytic leukemia), myeloid (acute myelogenous leukemia) and mast cell (mast cell tumor) origins [11].