NSCLC发生EGFR-TKIs耐药转化为SCLC的发生机制仍不清楚。目前,针对该机制学者们共提出了两种假说,分别为肿瘤异质性假说、NSCLC转化为SCLC假说。. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.