SLC5A2 and type 2 diabetes mellitus: For patients with T2D and CVD, sodium–glucose co-transporter 2 (SGLT2) inhibitors should be considered for use after metformin monotherapy in those with a GFR > 60 ml/min (or > 45 ml/min or above in countries where this is the indicated threshold for empagliflozin/canagliflozin prescribing).