SLC5A2 and Hypoglycemia: Although care should be taken to avoid hypoglycaemia and its associated increased risk of falls when treating frail elderly patients with T2D and CVD, it should be taken into account that the maximum CV benefits derived from the SGLT2 inhibitor empagliflozin in the EMPA-REG OUTCOME® study were seen among the older participants, and this population is also more likely to suffer from CV and renal comorbidities.