DPP4 and hydrops fetalis: CVOTs of the dipeptidyl peptidase 4 (DPP-4) inhibitors saxagliptin, alogliptin and sitagliptin have shown neutral results in which neither an increase nor a decrease was seen in the rate of ischaemic events in patients treated with these agents when compared with placebo, although the rate of hospitalisation for HF was increased for saxagliptin [35–37].