Recently published results from the real-world evidence observational study CVD-REAL, in which the risk of HHF in individuals with T2D who had been newly initiated on SGLT2 inhibitors (canagliflozin, dapagliflozin or empagliflozin) was compared to other glucose-lowering drugs (oGLD), have shown similar trends for risk reductions in HF and all-cause mortality associated with SGLT2 inhibitor use [47].This held true for all six countries involved in the study, despite differences in the background treatment and the use of different SGLT2 inhibitors in the US and Europe. This evidence concerns the gene SLC5A2 and hydrops fetalis.