In this perspective, an over-expressed lncRNA in HCC termed colon cancer associated transcript 1 (CCAT1) was found to competitively bind to let-7 (as evidenced by increased expression of let-7 target genes including high mobility group AT-hook2 and c-Myc), leading to increased proliferation and migration of HCC cells [48]. The gene discussed is MYC; the disease is hepatocellular carcinoma.