Similarly, two other lncRNAs Sprouty4-Intron 1 (SPRY4-IT1) and small nucleolar RNA host gene 20 (SNHG20) that are overexpressed in HCC have been shown to prompt EMT via up-regulating the transcription factors twist1 and Vimentin while reducing the expression of E-cadherin [60–62]. The gene discussed is SNHG20; the disease is hepatocellular carcinoma.